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LDH Shelter Stress Protocol — Dogs

Dosing, recheck and weaning support for LDH North Melbourne and Cranbourne. Implements the SOP Shelter Stress Management – Dogs v1.2 — see what changed. For veterinary use only. Tool version 1.2.

Animal attendants: check the Before You Flag guide first — environment, pain and enrichment checks, plus a note for the vet team.

Patient and vet
Screen for SSRIs (e.g. fluoxetine, paroxetine), SNRIs (e.g. venlafaxine), tricyclics, MAOIs, tramadol, ondansetron, mirtazapine, 5-HTP and St John's Wort. See the serotonin syndrome section below. Email the behaviour department if guidance is required.

Start shelter stress medication

Tick the signs the dog is showing, choose the drug, and the tool gives the dose, the tablet breakdown and a note you can paste into Teams or Sheltermate.

Arousal signs
    Fear or shut-down signs
      Body language reference charts — arousal and fear
      Medication
      Note for Teams or Sheltermate

      Treatment pathway

      Step 1
      Dog flagged for shelter stress
      Attendant, trainer or vet flags — see the Before You Flag guide for the environment, pain and enrichment checks to run first. Shelter Vet reviews the dog in pen, reads the observation chart, talks to the attendants, records an initial FAS score.
      Step 2
      Check for a diversion first
      • Court hold? Refer to the behaviour department (Q chat for NM, CB Court Hold AAs chat for CB) for a medication trial
      • Already on behaviour medication at admission? Behaviour department takes over medicating and monitoring
      Court hold dogs require behavioural medication approval by local government before commencing medication. Refer to the behaviour department for approval before starting behaviour medication.
      Exception: welfare concerns, self-trauma or property damage — the Shelter Vet team starts medication now, then refers for follow-up.
      Step 3A · Fear or shut-down
      Trazodone
      • Start 5 mg/kg BID, same for every dog regardless of size
      • Reassess in 48 to 72 hours, between 10am and 3pm
      • Ceiling 10 mg/kg BID
      • Ceiling 7 mg/kg BID on another serotonergic drug
      Step 3B · Aroused or reactive
      Clonidine
      • Start 0.02 mg/kg BID
      • Reassess in 48 to 72 hours, between 10am and 3pm
      • Short acting — twice daily will not cover the whole day
      • 1200 mcg compounded tablet only from 10 kg up; under 10 kg, 100 mcg and 150 mcg tablets also available
      • Ceiling 0.05 mg/kg BID
      Above either ceiling: refer to the behaviour department or behaviour veterinarian for welfare concerns.
      Step 4 · Reassess at 48–72 h
      Response to the first-line drug?
      • Partial response: increase the current drug by 25%. Pregabalin (2–10 mg/kg BID) can be added as an adjunct.
      • Ineffective — fear branch: trial clonidine.
      • Ineffective — arousal branch: add trazodone before trialling pregabalin. Keeping the current drug and increasing it by 25% is also an option.
      • Deteriorating or welfare concern: not a titration decision — escalate to the behaviour department now.
      Step 5 · At either ceiling
      Add the paired second-line drug
      • Do not titrate the first-line drug past its ceiling
      • Fear branch (trazodone at ceiling): add clonidine
      • Arousal branch (clonidine at ceiling): add trazodone, or pregabalin if trazodone isn't suitable
      • Titrate the add-on by 25% each check up to its own ceiling
      • Pregabalin: only 25 mg and 75 mg capsules, cannot be split — once at the smallest capsule, halve the frequency instead of the dose
      Above either ceiling: refer to the behaviour department or behaviour veterinarian rather than titrating further.
      Step 6 · At 4 weeks
      Consider long-term medication
      A dog still on trazodone at 4 weeks should be considered for long-term behaviour medication rather than continued short-acting treatment. Refer to the behaviour department for case management.
      Step 7 · At exit
      Adoption, foster or rescue
      Less than 14 days: stop at exit, no weaning. 14 to 28 days: wean over 2 weeks in the wean and discharge tool below (trazodone by mg/kg-gated 5-day steps; clonidine and pregabalin by a single 50% reduction). More than 28 days: wean over the 4-week ladder and have the discharge conversation.

      Recognising shelter stress

      Clinical signs

        How a dog gets flagged

        • Animal attendants or behaviour trainers post in the Attendants and Behaviour Department chat on Teams
        • Or flag the Shelter Vets directly on Teams
        • Or place a note on the S and I board for assessment
        • A Shelter Veterinarian then reviews the dog in pen, taking in the observation charts and attendant comments

        Who does what: behaviour vets advise on case management; shelter vets follow this procedure and escalate concerns; behaviour trainers and animal attendants flag dogs and help monitor.

        Body language reference charts

        Fear or shut-down signs point to trazodone first line; arousal or reactive signs point to clonidine first line.

        Monitoring in the shelter

        Reassessment schedule

        • Every 48 to 72 hours by a Shelter Veterinarian until the signs start to resolve
        • Then weekly Shelter Veterinarian reassessment
        • Check in between 10am and 3pm so short-acting medications are onboard when the dog is assessed

        What a reassessment covers

        • Review the FAS scores on the green Shelter Stress Medication Sheet, scored by the behaviour team
        • Read the daily observation notes on the pen
        • Talk to the animal attendants
        • FAS ladder: use the laminated chart in the sick and injured file box

        Concerned about progress? Liaise with the behaviour department or behaviour veterinarian in the Shelter Stress Cases chat on Teams.

        Serotonergic combinations and serotonin syndrome

        Trazodone is a serotonin antagonist and reuptake inhibitor. If the dog is already on another serotonergic medication, do not exceed 7 mg/kg PO BID and contact the behaviour department and behaviour veterinarian for case management advice — email the behaviour department if guidance is required.

        Screen for these before starting

        • SSRIs: fluoxetine, paroxetine, sertraline, citalopram
        • SNRIs: venlafaxine
        • Tricyclics: clomipramine, amitriptyline
        • MAOIs: selegiline
        • Opioid analgesics: tramadol
        • Antiemetics: ondansetron
        • Other: mirtazapine
        • Supplements: 5-HTP, St John's Wort

        Dogs admitted already on behaviour medication are the usual source. Those cases go to the behaviour department anyway.

        Recognise serotonin syndrome

        • Onset: 30 minutes to 12 hours after a dose
        • CNS: agitation, restlessness, vocalisation, mydriasis, ataxia, hyperreflexia, tremors, seizures
        • Autonomic: hyperthermia, tachycardia or bradycardia, hypertension, hypersalivation, panting
        • Gastrointestinal: vomiting, diarrhoea, abdominal pain
        • Neuromuscular: muscle rigidity, fasciculation, shivering

        Telling serotonin syndrome from arousal

        Serotonin syndrome almost always shows multiple signs across different body systems at once. Arousal is behavioural only — a dog that is pacing, vocalising, jumping and panting, but whose muscles and gait are normal, is not showing serotonin syndrome.

        • Gastrointestinal signs point away from arousal. Arousal does not cause vomiting, diarrhoea or abdominal pain.
        • Neuromuscular signs point away from arousal. Tremors, muscle rigidity, fasciculation, shivering, ataxia and hyperreflexia are not features of an aroused dog.
        • Seizures are never arousal.
        • Agitation or irritability WITH muscle changes is the combination to act on — not agitation alone.
        • Hyperthermia with tremors or rigidity is an emergency. Treat and refer, do not reassess in 48 to 72 hours.
        • Timing helps: serotonin syndrome appears 30 minutes to 12 hours after a dose and is a step change from the dog's baseline. Shelter stress builds gradually over days.
        • If in doubt, treat as serotonin syndrome. Do not increase the dose of a dog on a serotonergic combination that has become more agitated until this has been excluded.

        If suspected

        • Stop all serotonergic medications immediately
        • Cyproheptadine 1.1 mg/kg PO or per rectum every 4 to 6 hours (crush and mix with saline if needed)
        • Alternative: chlorpromazine 0.2 to 0.5 mg/kg IV, IM or SC every 6 hours
        • Supportive care: IV crystalloids 10 to 20 mL/kg bolus for hypovolaemia, active cooling for hyperthermia, methocarbamol for tremors
        • Seizures: diazepam or midazolam as indicated
        • Refer to a 24 hour emergency facility if severe or refractory
        • With treatment, signs resolve over 24 to 72 hours

        Documentation and discharge

        Once the dog is on a set dose

        • Update the Sheltermate indemnity with the weaning schedule
        • At adoption, foster or rescue, record the medication dispensed on Sheltermate so follow-up is possible

        The Customer Experience or Pathways team flags the dog for a vet discussion at the point of exit.

        What to tell the adopter, carer or rescue

        • Walk through the weaning schedule week by week and hand over the labelled medication
        • Monitor for any increase in anxiety, change in behaviour, or change in physical health
        • If the dog deteriorates, stop reducing and get in touch rather than pushing on with the schedule
        • Ongoing advice: Post-Adoption Behaviour Support at The Lost Dogs' Home, who liaise with the behaviour veterinarian if needed
        • Urgent help: The Lost Dogs' Home Veterinary Hospital

        What changed

        This tool follows SOP v1.2. If you learned the protocol under an earlier version, these are the changes.

        SOP v1.2
        TopicSOP v1.1SOP v1.2 and this tool
        First-line drug Trazodone first line for every dog, regardless of size or presentation Branches at first presentation: fear or shut-down starts trazodone, aroused or reactive starts clonidine — same starting doses as before
        Second line, at the ceiling or ineffective One add-on chosen on the presenting signs: clonidine for arousal, pregabalin for fear Branch-paired: fear branch adds clonidine; arousal branch adds trazodone, or pregabalin if trazodone isn't suitable. If ineffective below the ceiling, the paired drug can be trialled immediately rather than waiting to reach it — keeping the current drug and increasing it by 25% is also always an option
        Partial response Not specified separately from ineffective — both simply titrated the current drug by 25% Increase the current drug by 25%, as before. Pregabalin can now also be offered as an adjunct on a partial response, in either branch
        Clonidine strengths 100 mcg, 150 mcg and 1200 mcg tablets offered to every dog 1200 mcg compounded tablet only from 10 kg up. Under 10 kg, 100 mcg and 150 mcg tablets stay available
        Dose selection A "dose actually given" dropdown let the vet override to any achievable tablet combination Dropdown removed — the calculated nearest achievable dose is used directly
        Serotonergic screening Generic drug-class list Named examples added (fluoxetine, paroxetine, venlafaxine); email the behaviour department if guidance is required
        Court hold Listed alongside the other diversion checks Called out as a standout requirement: approval by local government before commencing medication, refer to the behaviour department
        Recheck signs Not recorded at recheck, only at the start Fear, arousal and improved signs can be ticked at each recheck, with a prompt to check in with an animal attendant first and chart for 30–60 seconds at the FOP
        For veterinary use only. Decision support, not a substitute for clinical judgement. Doses must be checked against the dog's current weight and clinical status before dispensing.

        © 2026 Juliana Xue. All rights reserved.
        This work is the intellectual property of Juliana Xue and may not be copied, modified, distributed or used without her express written permission, except by her current employer for as long as she remains engaged there.